Keratoconus is a disorder of the eye which results in progressive thinning of the cornea and ultimately causes the cornea to weaken and bulge outward. This abnormal curvature of the cornea is often in the lower half of the cornea and initially leads to astigmatism. Of course, It should be noted, however, that all cases of astigmatism are not due to keratoconus. In mild cases or in the early stages of keratoconus, eyeglasses can be worn to correct the astigmatism. So far, there has not been a treatment for slowing down the progression of keratoconus in the world. All treatments such as eyeglasses, contact lenses, intrastromal corneal ring segment have helped to correct only a part of the patient's vision.
Fortunately, in recent years, cross-linking surgery is the only method to stop the progression of keratoconus and completely carried out in Tehran-Iran Noor Eye Hospital.
Introduction to Corneal collagen cross-linking (UVX) as a treatment for keratoconus
In this surgery, creating more transverse ligaments in the corneal collagen tissue using riboflavin causes more corneal strength. The transverse ligaments in the cornea are like hooks and are responsible for preventing corneal bulge and irregularity.
Mechanism of thinning and weakening of the cornea
Young adults are susceptible to the accumulation of free oxygen radicals in their eyes. Under normal conditions, these free radicals are decomposed by the superoxide dismutase enzyme and do not harm the eyes. Some patients can not produce these protective enzymes. Eventually, the accumulation of these free radicals will damage the cornea tissue and reduce the strength of the cornea.