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February 18, 2007
Cataract Surgery Is Associated with a Higher Rate of Photodynamic Therapy for Age-Related Macular Degeneration
Ophthalmology Volume 114, Issue 2 , February 2007, Pages 278-282
Fifty (0.85%) cataract patients and 94 control cases (0.32%) underwent PDT after cataract surgery (P<0.0001, chi-square test). A significant rise in PDT rate was noticed in cataract patients compared to controls during the first 6 months after surgery (P = 0.004, chi-square test). Between 6 and 12 months postoperatively, the PDT rates were similar in both groups. However, a more significant rise in PDT rates occurred between 1 and 1.5 years after surgery (P<0.0001, chi-square test). The Kaplan–Meier PDT-free survival curve of cataract patients was significantly worse than that of the controls (P<0.0001, chi-square test; P = 33.7, log-rank test). The hazard ratio for cataract patients compared to controls to undergo PDT after surgery was 2.7 (confidence interval = 2.4–5.7). The most significant factors to reduce the time to PDT were advanced age followed by having had cataract surgery, place of birth, socioeconomic status, and hyperlipidemia (Cox proportional hazards survival regression).
Conclusions
We identified an increased rate of PDT, presumably for subfoveal AMD, 1 to 1.5 years after cataract surgery.
Posted by mmiraftab at February 18, 2007 11:25 AM