May 26, 2003
Lutein and Zeaxanthin Status and Risk of Age-Related Macular Degeneration
Investigative Ophthalmology and Visual Science. 2003;44:2461-2465.
Risk of age-related macular degeneration (early or late) was significantly higher in people with lower plasma concentrations of zeaxanthin. Compared with those whose plasma concentrations of zeaxanthin were in the highest third of the distribution, people whose plasma concentration was in the lowest third had an odds ratio for risk of age-related macular degeneration of 2.0 (95% confidence interval [CI] 1.0–4.1), after adjustment for age and other risk factors. Risk of age-related macular degeneration was increased in people with the lowest plasma concentrations of lutein plus zeaxanthin (odds ratio [OR] 1.9, 95% CI 0.9–3.5) and in those with the lowest concentrations of lutein (OR 1.7, 95% CI 0.9–3.3), but neither of these relations was statistically significant.These findings provide support for the view that zeaxanthin may protect against age-related macular degeneration.
Posted by mmiraftab at May 26, 2003 11:09 PM