January 24, 2003
Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy?
Current Opinion in Ophthalmology 2002; 13(6):362-370
Lawrence M. Buono, MD; Rod Foroozan, MD; Robert C. Sergott, MD; Peter J. Savino, MD
Normal tension glaucoma and dominant optic atrophy share many overlapping clinical features, and differentiating between these two diseases is often difficult. The gene responsible for dominant optic atrophy is the OPA1 gene located on chromosome 3. This gene encodes for a protein product that is involved in mitochondrial metabolic function. Recent genetic linkage analysis of patients with normal tension glaucoma has shown an association with polymorphisms of the OPA1 gene. This association suggests that normal tension glaucoma may actually be a hereditary optic neuropathy with a pathophysiology based in mitochondrial dysfunction.
read also more in EDITORIAL of Optic neuropathy (The OPA1 gene and optic neuropathy) in BMJ
Posted by M.Miraftab MD,
Posted by mmiraftab at January 24, 2003 02:57 AM